4/14/2023 0 Comments Think cell license key 2018![]() ![]() This revealed that the shape of intestinal cells explains why the newly formed cells become separated. used live microscopy techniques to watch in real time as new cells divide and position themselves in mouse intestinal organoids – miniature versions of organs that can be grown outside the body. ![]() To investigate how this happens, McKinley et al. But when cells in the intestine divide, the new cells often separate, ending up on either side of a cell that did not divide. In many tissues the resulting cells sit side-by-side. New cells form when existing cells double their contents and divide. This means that the new cells need to occupy similar positions to the ones they are replacing to keep the intestine working. The lining contains many different cell types, which exchange important signals with their neighbors. This can happen rapidly for example, the lining of the intestine renews itself approximately every five days. The body has an impressive ability to renew itself by replacing old and damaged cells with new ones. Our results reveal that the process of cytokinesis in elongated mammalian epithelia allows lineages to intermix and that cellular aspect ratio is a critical modulator of the progeny pattern. ![]() Cellular aspect ratio is similarly a key parameter for division-coupled interspersion in the early mouse embryo, suggesting that this physical mechanism for patterning progeny may pertain to many mammalian epithelia. Reducing the cellular aspect ratio to minimize the height difference between interphase and mitotic cells disrupts interspersion, producing contiguous patches. Using light sheet and confocal imaging of intestinal organoids, we show that lineages intersperse during cytokinesis, when elongated interphase cells insert between apically displaced daughters. The mechanisms that generate these distinct patterns of progeny are poorly understood. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. Cell division is essential to expand, shape, and replenish epithelia.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |